2-Chloro-5-nitro-3-(trifluoromethyl)pyridine → 6-Chloro-5-(trifluoromethyl)pyridin-3-amine

HRID 41976ノート

反応式

HRID 41976 の反応式
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N+:12]([O-])=O)=[CH:4][N:3]=1>C(OCC)(=O)C.[Zn+2].[Br-].[Br-]>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([NH2:12])=[CH:6][C:7]=1[C:8]([F:11])([F:9])[F:10]

参加物

4

反応物 1

HCID 38491402-Chloro-5-nitro-3-(trifluoromethyl)pyridine

生成物 1

HCID 135322446-Chloro-5-(trifluoromethyl)pyridin-3-amine収率 92.1%

試薬・触媒・溶媒 2

HCID 10421208Zinc bromide触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (5.25 mmol, 1.19 g), ZnBr2 (1.05 mmol, 0.200 g) and 5% Pt (C) (1.58 mmol, 0.31 g) in ethyl acetate (50 ml) was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off and the solid was washed with warmed ethanol. The solvent was evaporated affording the expected product (0.95 g, yield 92%).

後処理

  1. filtrationThe catalyst was filtered off
  2. washthe solid was washed with warmed ethanol
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-dd5d5aedb746487fad31455fd2cacb7e
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

反応ノート

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