関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosphorus oxybromide | HCID 24613 | — |
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | 5-Nitro-3-phenylpyridin-2-ol | HCID 178526835 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Bromo-5-nitro-3-phenylpyridine | HCID 86657253 | 62% |
反応手順
A mixture of 5-nitro-3-phenylpyridin-2-ol (4.63 mmol, 1 g), POBr3 (4.74 mmol, 0.45 ml) and PBr3 (4.71 mmol, 1.4 g) was heated at 120° C. for 3.5 hours. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The organic phase was dried and evaporated affording 0.8 g (yield 62%) of the expected product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08536165B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-da2a4b647a9443d59f2c8767e3498714 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
