4-Chlorophenyl isothiocyanate → Ethyl 1-{[(4-chlorophenyl)amino]thioxomethyl}piperidine-4-carboxylate

HRID 419845ノート

反応式

HRID 419845 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[NH:11]1[CH2:21][CH2:20][CH:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:13][CH2:12]1>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:11]2[CH2:21][CH2:20][CH:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:13][CH2:12]2)=[S:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 164804-Chlorophenyl isothiocyanateHCID 70770Ethyl 4-piperidinecarboxylate

生成物 1

HCID 4232750Ethyl 1-{[(4-chlorophenyl)amino]thioxomethyl}piperidine-4-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 4-chlorophenyl isothiocyanate (3.5 g, 20.7 mmol), and ethyl isonipecotate (3.19 mL, 20.7 mmol) in dichloromethane (30 mL) was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, the residue was triturated with ether and the resulting solid was filtered off and dried to afford the title compound as a white solid, 6.27 g.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe residue was triturated with ether
  3. filtrationthe resulting solid was filtered off
  4. customdried

出典と根拠

ORDレコード
ord-76c52aa985ef4e53822637a1a51a0ad5
出典データセット
uspto-grants-2012_01
特許番号
US08093400B2

反応ノート

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