Water → 1-Bromo-3-cyclopropoxybenzene

HRID 42009

反応式

HRID 42009 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH:10]1[CH2:12][CH2:11]1.C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C.C(OCC)C>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH:10]2[CH2:12][CH2:11]2)[CH:3]=1

参加物

7

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 115633-BromophenolHCID 78037Bromocyclopropane

生成物 1

HCID 574169511-Bromo-3-cyclopropoxybenzene収率 83.1%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
180 °C

実験手順

A mixture of 3-bromophenol (4.80 mmol, 0.83 g), bromocyclopropane (27.71 mmol, 2.22 ml), K2CO3 (23.15 mmol, 3.2 g) in DMF (18 ml) was heated at 180° C. for 8 hours in a microwave oven. Water and diethyl ether were added and the organic phase was evaporated affording 0.85 g of the expected product.

後処理

  1. customthe organic phase was evaporated

出典と根拠

ORDレコード
ord-34589bfa5226443b9088b777e4c58fe9
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

関連ノート

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