Water → 1-Bromo-3-cyclopropoxybenzene
反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH:10]1[CH2:12][CH2:11]1.C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C.C(OCC)C>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH:10]2[CH2:12][CH2:11]2)[CH:3]=1参加物
7
反応条件
- 温度
- 180 °C
実験手順
A mixture of 3-bromophenol (4.80 mmol, 0.83 g), bromocyclopropane (27.71 mmol, 2.22 ml), K2CO3 (23.15 mmol, 3.2 g) in DMF (18 ml) was heated at 180° C. for 8 hours in a microwave oven. Water and diethyl ether were added and the organic phase was evaporated affording 0.85 g of the expected product.
後処理
- customthe organic phase was evaporated
出典と根拠
- ORDレコード
- ord-34589bfa5226443b9088b777e4c58fe9
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536165B2
反応ノート
読み込み中…