Hydrochloric Acid → 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid

HRID 420143ノート

反応式

HRID 420143 の反応式
[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:18][CH3:19])[CH:9]=[C:10]([C:13]([O:15]CC)=[O:14])[CH:11]=3)[CH:6]=[CH:5]2)[CH2:3][CH2:2]1.Cl>CO>[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:18][CH3:19])[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=3)[CH:6]=[CH:5]2)[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66649481ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate

生成物 1

HCID 666494031-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid収率 102.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

35 ml of 5N NaOHaq was added to a solution of 15.15 g of ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate in MeOH and the mixture was stirred at 60° C. for 8 hrs. The mixture was cooled to 0° C. and 35 ml of 5N HCl was added thereto. The precipitate was filtered and dried in vacuo to give 13.8 g of 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid as a colorless solid.

後処理

  1. temperatureThe mixture was cooled to 0° C.
  2. filtrationThe precipitate was filtered
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-2658d04a79664bfc89460908213bc932
出典データセット
uspto-grants-2012_01
特許番号
US08093389B2

反応ノート

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