HCID 178451554、化合物 → HCID 178515376、化合物

HRID 420151ノート

反応式

HRID 420151 の反応式
[O:1]=[C:2]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:24]3[NH:28][N:27]=[N:26][N:25]=3)[CH:22]=2)[O:17][C:4]2([CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2)[CH2:3]1>Cl.O1CCOCC1>[NH:28]1[C:24]([C:21]2[CH:22]=[C:23]3[C:18](=[CH:19][CH:20]=2)[O:17][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][C:2]3=[O:1])=[N:25][N:26]=[N:27]1

参加物

3

反応物 1

HCID 178451554HCID 178451554、化合物

生成物 1

HCID 178515376HCID 178515376、化合物

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

4 N HCl-1,4-dioxane (200 mL) was added to 40.6 g tert-butyl 4-oxo-6-(1H-tetrazol-5-yl)spiro[chroman-2,4′-piperidine]-1′-carboxylate produced in Reference Example 17, and stirred at room temperature for 5 hours. The reaction mixture was concentrated, and the residue was triturated with methanol. The insoluble solid was collected through filtration, and dried under reduced pressure to obtain 6-(1H-tetrazol-5-yl)-spiro[chroman-2,4′-piperidine]-4-one as a colorless solid.

後処理

  1. customproduced in Reference Example 17
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was triturated with methanol
  4. filtrationThe insoluble solid was collected through filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-498688e63a1e444296f256c3e128be1b
出典データセット
uspto-grants-2012_01
特許番号
US08093389B2

反応ノート

読み込み中…