2-Chloro-5-nitro-3-(trifluoromethyl)pyridine → 6-Chloro-5-(trifluoromethyl)pyridin-3-amine

HRID 42041ノート

反応式

HRID 42041 の反応式
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N+:12]([O-])=O)=[CH:4][N:3]=1>C(OCC)(=O)C.[Zn+2].[Br-].[Br-]>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([NH2:12])=[CH:6][C:7]=1[C:8]([F:11])([F:9])[F:10]

参加物

4

反応物 1

HCID 38491402-Chloro-5-nitro-3-(trifluoromethyl)pyridine

生成物 1

HCID 135322446-Chloro-5-(trifluoromethyl)pyridin-3-amine収率 92.1%

試薬・触媒・溶媒 2

HCID 10421208Zinc bromide触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (5.25 mmol, 1.19 g), ZnBr2 (1.05 mmol, 0.200 g) and 5% Pt © (1.58 mmol, 0.31 g) in ethyl acetate (50 ml) was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off and the solid was washed with warmed ethanol. The solvent was evaporated affording the expected product (0.95 g, yield 92%).

後処理

  1. filtrationThe catalyst was filtered off
  2. washthe solid was washed with warmed ethanol
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-b481c66872354ee5870e85cbf0e7fd28
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

反応ノート

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