Chloroacetaldehyde → Methyl 6-bromoimidazo[1,2-a]pyridine-7-carboxylate

HRID 420520ノート

反応式

HRID 420520 の反応式
[CH3:1][O:2][C:3](=[O:12])[C:4]1[C:9]([Br:10])=[CH:8][N:7]=[C:6]([NH2:11])[CH:5]=1.C([O-])(O)=O.[Na+].Cl[CH2:19][CH:20]=O>CCO>[CH3:1][O:2][C:3]([C:4]1[C:9]([Br:10])=[CH:8][N:7]2[CH:19]=[CH:20][N:11]=[C:6]2[CH:5]=1)=[O:12]

参加物

5

反応物 3

HCID 33ChloroacetaldehydeHCID 516892Sodium BicarbonateHCID 25307230Methyl 2-amino-5-bromoisonicotinate

生成物 1

HCID 57906576Methyl 6-bromoimidazo[1,2-a]pyridine-7-carboxylate収率 91.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-amino-5-bromo-isonicotinic acid methyl ester (500 mg, 2.16 mmol), NaHCO3 (309 mg, 3.68 mmol) and chloracetaldehyde (1.16 mL, 9.8 mmol) in EtOH (15 mL) was vigorously stirred and refluxed for 14 h. The reaction mixture was cooled to RT, concentrated under vacuum and the remaining residue was suspended in AcOEt (100 mL). The organic fraction was washed with water (2×50 mL), then dried over Na2SO4, filtered, and evaporated. The residue was purified by Combi-Flash Companion™ (Isco Inc.) column chromatography (SiO2; gradient elution, [hexane/DCM 1:1]/TBME 95:5-100% TBME) to yield the title compound (505 mg, 1.98 mmol, 91%). MS: 255 [M+1]+; HPLC: AtRet=0.58 TLC: RF 0.16 (hexane/DCM/TBME 1:1:2).

後処理

  1. temperaturerefluxed for 14 h
  2. concentrationconcentrated under vacuum
  3. washThe organic fraction was washed with water (2×50 mL)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated
  7. customThe residue was purified by Combi-Flash Companion™ (Isco Inc.) column chromatography (SiO2; gradient elution, [hexane/DCM 1:1]/TBME 95:5-100% TBME)

出典と根拠

ORDレコード
ord-094f558165b94efeadd276b2003c215a
出典データセット
uspto-grants-2012_01
特許番号
US08097617B2

反応ノート

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