Ammonia → 2-Amino-6-methoxy-3-nitropyridine

HRID 420695

反応式

HRID 420695 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.CO.[NH3:15]>>[CH3:12][O:11][C:4]1[N:3]=[C:2]([NH2:15])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 222Ammonia2 回HCID 887MethanolHCID 27950292-Chloro-6-methoxy-3-nitropyridine

生成物 1

HCID 38524282-Amino-6-methoxy-3-nitropyridine収率 84%

実験手順

A solution/suspension of 2-chloro-6-(methyloxy)-3-nitropyridine (65.7 g, 348 mmol) in 2M ammonia in MeOH (500 ml, 1000 mmol) and aqueous ammonia (500 ml, 348 mmol) was stirred at 65° C. for 18 h. The reaction was cooled down and the solid filtered off and washed with water (2×100 ml). The solid was dried in the vacuum oven at 40° C. overnight to afford the product as a bright yellow solid (52.14 g, 84% purity by NMR, 74%).

後処理

  1. temperatureThe reaction was cooled down
  2. filtrationthe solid filtered off
  3. washwashed with water (2×100 ml)
  4. customThe solid was dried in the vacuum oven at 40° C. overnight

出典と根拠

ORDレコード
ord-807a40d4d2504daaa06ee2832043c653
出典データセット
uspto-grants-2012_01
特許番号
US08097628B2

関連ノート

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