関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (6-Chloro-5-methylpyridin-3-yl)methanol | HCID 11686949 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-Chloro-5-methylpyridine-3-carbaldehyde | HCID 19710681 | 69.1% |
反応手順
A mixture of (6-chloro-5-methyl-3-pyridinyl)methanol (300 mg, 1.904 mmol), CrO2 (Magtrieve) (2.398 g, 28.5 mmol), and DCM (15 ml) was stirred at 40° C. in a closed tube overnight. TLC showed some starting material remaining. Additional CrO2 (0.8 g) was added. After heating 4 additional hours, TLC showed full conversion. Filtration and concentration afforded 6-chloro-5-methyl-3-pyridinecarbaldehyde (204.8 mg, 69%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08097628B2 |
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| 出典データセット | uspto-grants-2012_01 |
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| ORD ID | ord-a96b34040b734cec8923f0d39fc8cb8d |
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| 出典メモ | uspto-grants-2012_01 |
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