化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Methyl 2-chloro-4-methylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-Chloro-4-methylbenzoic acid | HCID 2735755 | — |
| 生成物 | Methyl 2-chloro-4-methylbenzoate | HCID 22019481 | — |
反応手順
2-chloro-4-methylbenzoic acid (500 mg, 2.93 mmol) was dissolved in Methanol (7 mL) and SOCl2 (0.215 mL, 2.93 mmol) was slowly added to the mixture and the reaction was left at room temperature overnight. Next morning HPLC showed completion. Volatiles were removed under vacuum to afford 526 mg of the title compound as brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08097628B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-816d5ce1e99a4848bd036311ac824933 |
| 出典メモ | uspto-grants-2012_01 |