Hydrochloric Acid → (2S)-5-(1,3,5Trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine dihydrochloride
反応式
[ClH:1].[CH3:2][N:3]1[C:7]([CH3:8])=[C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:10]=2[CH2:11][CH2:12][C@H:13]([NH2:19])[CH2:14]3)[C:5]([CH3:20])=[N:4]1>CCOCC>[ClH:1].[ClH:1].[CH3:2][N:3]1[C:7]([CH3:8])=[C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:10]=2[CH2:11][CH2:12][C@H:13]([NH2:19])[CH2:14]3)[C:5]([CH3:20])=[N:4]1参加物
4
実験手順
HCl (0.42 mL, 4 M solution in dioxane, 1.688 mmol) was dropwise added to a suspension of (2S)-5-(1,3,5-Trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine (0.143 g, 0.563 mmol) in Et2O (5 mL). The reaction mixture was stirred at room temperature for 3 h and then the solvent was concentrated off. The resulting solid was suspended in Et2O (10 mL) and concentrated, in order to remove excess of HCl. This operation was repeated for three times, to give 0.150 g of the title product (Rf=0.2 (AcOEt/MeOH/Et3N 20:3:2), white solid, 91% yield).