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Hydrochloric Acid → 1-benzhydrylazetidin-3-ol Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-(Diphenylmethyl)azetidin-3-ol | HCID 330448 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-benzhydrylazetidin-3-ol Hydrochloride | HCID 2801726 | 100% |
反応手順
1-(Diphenylmethyl)-3-hydroxyazetidine (9.70 g) was suspended in 4.5 M HCl in EtOAc (35 mL) at room temperature and stirred for 10 min. The solvent was then evaporated to dryness to give 1-(diphenylmethyl)-3-hydroxyazetidine hydrochloride (12.0 g, 100%). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 7.30-7.70 (10H, m), 5.85 (1H, s), 5.80 (1H, d), 4.46 (1H, m), 3.70-4.20 (4H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536160B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-0cd66641d3cf44f0803004b3573e23f5 |
| 出典メモ | uspto-grants-2013_09 |