Sodium Bicarbonate → 6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline

HRID 420796ノート

反応式

HRID 420796 の反応式
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[Cl:13])[CH2:9][NH:8][CH2:7][CH2:6]2.C([O-])(O)=O.[Na+]>O.C(Cl)Cl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[Cl:13])[CH2:9][NH:8][CH2:7][CH2:6]2

参加物

5

反応物 2

HCID 516892Sodium BicarbonateHCID 125950786,7-Dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

生成物 1

HCID 125950776,7-Dichloro-1,2,3,4-tetrahydroisoquinoline収率 100.7%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

6,7-dichloro-1,2,3,4-tetrahydroisoquinoline HCl salt (550 mg, 2.31 mmol) was dissolved in water (5 mL) and DCM (20 mL). Aqueous saturated NaHCO3 (10 mL) was added and the organic phase was separated. The aqueous phase was extracted twice with DCM (20 mL), the organic phases were combined, dried (Na2SO4), and filtered to give 6,7-dichloro-1,2,3,4-tetrahydro-isoquinoline (470 mg, quant.).

後処理

  1. customthe organic phase was separated
  2. extractionThe aqueous phase was extracted twice with DCM (20 mL)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-2d46b5ffb69548b0a33cbe121da15847
出典データセット
uspto-grants-2012_01
特許番号
US08097636B2

反応ノート

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