Benzenecarboximidic acid, ethyl ester, hydrochloride (1:1) → HCID 58986339、化合物

HRID 420813

反応式

HRID 420813 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10]([C:19]([NH:21][NH2:22])=[O:20])=[C:9]1[CH:23]([CH3:25])[CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[C:27](=N)(OCC)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CCO>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10]([C:19]2[O:20][C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[N:22][N:21]=2)=[C:9]1[CH:23]([CH3:25])[CH3:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 79249Benzenecarboximidic acid, ethyl ester, hydrochloride (1:1)HCID 58986340HCID 58986340、化合物2 回

生成物 1

HCID 58986339HCID 58986339、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of 1-benzyl-2-isopropyl-5-methoxy-1H-indole-3-carbohydrazide (Compound 35, 25 mg, 0.074 mmol) in EtOH (2.0 ml) was added ethyl benzimidate hydrochloride (Fluka, 21 mg, 0.11 mmol). The mixture was stirred at 80° C. for 4 h and was concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes to yield 2-(1-benzyl-2-isopropyl-5-methoxy-1H-indol-3-yl)-5-phenyl-1,3,4-oxadiazole (Compound 36) as a white solid.

後処理

  1. concentrationwas concentrated in vacuo
  2. customThe residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes

出典と根拠

ORDレコード
ord-c5c217d05f704a728dc0590b85acc8fc
出典データセット
uspto-grants-2012_01
特許番号
US08097644B2

関連ノート

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