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4-Chloro-3-fluorophenylboronic Acid → 5-(3-Fluoro-4-chlorophenoxy)-2-ethoxycarbonylmethyl-1-phenylindole-3-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-3-fluorophenylboronic Acid | HCID 2778656 | — |
| 反応物 | 2-Ethoxycarbonylmethyl-5-hydroxy-1-phenylindole-3-carboxylic acid ethyl ester | HCID 66657544 | — |
| 生成物 | 5-(3-Fluoro-4-chlorophenoxy)-2-ethoxycarbonylmethyl-1-phenylindole-3-carboxylic acid ethyl ester | HCID 66657561 | — |
反応手順
The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-5-hydroxy-1-phenylindole-3-carboxylic acid ethyl ester (140 mg, 0.38 mmol, see step (b) Example 3) and 3-fluoro-4-chlorophenylboronic acid (133 mg, 0.76 mmol). Yield 103 mg (54%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08097623B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-c181ee1c470548e096cca8a0848ed6fe |
| 出典メモ | uspto-grants-2012_01 |