5-Chlorosalicylic Acid → 2-(5-Chloro-2-hydroxybenzoyl)amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylic acid ethyl ester

反応式

[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[CH2:12]([O:14][C:15]([C:17]1[C:18]2[CH2:26][CH2:25][CH2:24][CH2:23][C:19]=2[S:20][C:21]=1[NH2:22])=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[C:18]2[CH2:26][CH2:25][CH2:24][CH2:23][C:19]=2[S:20][C:21]=1[NH:22][C:7](=[O:9])[C:6]1[CH:10]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[OH:11])=[O:16])[CH3:13]

参加物

反応物 2

HCID 94475-Chlorosalicylic Acid

HCID 78262Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

生成物 1

HCID 100683112-(5-Chloro-2-hydroxybenzoyl)amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylic acid ethyl ester収率 49.6%

実験手順

Using 5-chlorosalicylic acid and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester as the raw materials, the same operation as the example 16 gave the title compound.

出典と根拠

ORDレコード: ord-6fc37020a02a42d1969ea4ec412bb822
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08097759B2

反応ノート

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