Water → 4,5-Diethyloxazol-2-amine
反応式
[CH3:1][CH2:2][C:3](=O)[CH:4]([CH2:6][CH3:7])[OH:5].[N:9]#[C:10][NH2:11].[O-]CC.[Na+].O>C(O)C>[NH2:11][C:10]1[O:5][C:4]([CH2:6][CH3:7])=[C:3]([CH2:2][CH3:1])[N:9]=1参加物
6
実験手順
Propioin (1.03 g, 8.37 mmol) was dissolved in ethanol (15 mL). Cyanamide (0.75 g, 17.7 mmol) and sodium ethoxide (1.21 g, 17.7 mmol) were added, and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was poured into water and extracted with ethyl acetate. After the organic layer was washed with water and brine, dried over anhydrous sodium sulfate, the residue obtained by evaporation under reduced pressure was purified by chromatography on silica gel (dichloromethane:methanol=9:1) to give the title compound (369.2 mg, 29.7%) as a yellow amorphous.
後処理
- extractionextracted with ethyl acetate
- washAfter the organic layer was washed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- customthe residue obtained by evaporation under reduced pressure
- customwas purified by chromatography on silica gel (dichloromethane:methanol=9:1)
出典と根拠
- ORDレコード
- ord-dc9178b141b9494d9295114ee8c3f8ba
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08097759B2
反応ノート
読み込み中…