5-Bromo-2-acetylsalicylic acid → 2-Acetoxy-5-bromo-N-(4,5-diethyloxazol-2-yl)benzamide

反応式

[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([OH:9])=O)(=[O:3])[CH3:2].[NH2:15][C:16]1[O:17][C:18]([CH2:23][CH3:24])=[C:19]([CH2:21][CH3:22])[N:20]=1>>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([NH:15][C:16]1[O:17][C:18]([CH2:23][CH3:24])=[C:19]([CH2:21][CH3:22])[N:20]=1)=[O:9])(=[O:3])[CH3:2]

参加物

反応物 2

HCID 739225-Bromo-2-acetylsalicylic acid

HCID 178601934,5-Diethyloxazol-2-amine

生成物 1

HCID 178601192-Acetoxy-5-bromo-N-(4,5-diethyloxazol-2-yl)benzamide収率 22%

実験手順

Using 2-acetoxy-5-bromobenzoic acid and 2-amino-4,5-diethyloxazole as the raw materials, the same operation as the example 24 gave the title compound. (2-Acetoxy-5-bromobeazoic acid: refer to Eur. J. Med. Chem., 1996, 31, 861.)

出典と根拠

ORDレコード: ord-401a22af503d4fb59fae26283c50caa8
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08097759B2

反応ノート

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