化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Ethoxy-N-[2-(phenylsulfonyl)ethyl]-1-propanamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | ((2-Chloroethyl)sulphonyl)benzene | HCID 13646 | — |
| 反応物 | Propanolamine ethyl ether | HCID 22720 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-Ethoxy-N-[2-(phenylsulfonyl)ethyl]-1-propanamine hydrochloride | HCID 13655085 | 63.2% |
反応手順
A mixture of 51.4 g (0.253 mole) of 2-chloroethyl phenyl sulfone, 50.2 g (0.417 mole) of 3-ethoxy-1-propanamine, and 33.0 g (0.327 mole) of triethylamine in 400 ml of acetonitrile was stirred at room temperature for 20 hr. The solvent was removed in vacuo and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride phase was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, an excess of ethereal hydrogen chloride was added and ether was added. A precipitate was collected to give 49.2 g (63.2%) of white crystalline solid, m.p. 169°-170° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04724235 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-b9ffe40dfc354894b3753bf7aa940b3d |
| 出典メモ | uspto-grants-1988_02 |