5-Bromosalicylic acid → 5-Bromo-2-hydroxy-N-[2-morpholino-5-(trifluoromethyl)phenyl]-benzamide

HRID 421111

反応式

HRID 421111 の反応式
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][C:19]=2[NH2:20])[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:20][C:19]1[CH:21]=[C:22]([C:25]([F:26])([F:27])[F:28])[CH:23]=[CH:24][C:18]=1[N:15]1[CH2:14][CH2:13][O:12][CH2:17][CH2:16]1)=[O:9]

参加物

3

反応物 2

HCID 69725-Bromosalicylic acidHCID 136624N-(2-Amino-4-(trifluoromethyl)phenyl)morpholine

生成物 1

HCID 100721825-Bromo-2-hydroxy-N-[2-morpholino-5-(trifluoromethyl)phenyl]-benzamide収率 65.9%

実験手順

Using 5-bromosalicylic acid and 2-morpholino-5-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

出典と根拠

ORDレコード
ord-0bb81198c0f9440a905d890a8b160351
出典データセット
uspto-grants-2012_01
特許番号
US08097759B2

関連ノート

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