5-Bromosalicylic acid → 2-(5-Bromo-2-hydroxybenzoyl)amino 4-(trifluoromethyl)thiazole-5-carboxylic acid ethyl ester

反応式

[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[CH2:12]([O:14][C:15]([C:17]1[S:21][C:20]([NH2:22])=[N:19][C:18]=1[C:23]([F:26])([F:25])[F:24])=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[S:21][C:20]([NH:22][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[OH:11])=[N:19][C:18]=1[C:23]([F:25])([F:26])[F:24])=[O:16])[CH3:13]

参加物

反応物 2

HCID 69725-Bromosalicylic acid

HCID 676565-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester

生成物 1

HCID 865955442-(5-Bromo-2-hydroxybenzoyl)amino 4-(trifluoromethyl)thiazole-5-carboxylic acid ethyl ester収率 88.7%

実験手順

Using 5-bromosalicylic acid and 2-amino-4-(trifluoromethyl)thiazole-5-carboxylic acid ethyl ester as the raw materials, the same operation as the example 195(3) gave the title compound.

出典と根拠

ORDレコード: ord-858afd1fb6d84c0799541798cd27449d
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08097759B2

反応ノート

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