1-Bromodecane → 2-(Decylthio)ethanol

HRID 421559

反応式

HRID 421559 の反応式
[C:1](=[O:4])([O-])[O-].[K+].[K+].[CH2:7](Br)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[SH:18][CH:19](O)C>CC(C)=O>[CH2:7]([S:18][CH2:19][CH2:1][OH:4])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

5

反応物 3

HCID 81731-BromodecaneHCID 11430Potassium CarbonateHCID 4713212Mercapto-ethanol

生成物 1

HCID 966542-(Decylthio)ethanol収率 94%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Under nitrogen, to a suspension of potassium carbonate (27 g, 200 mmol) in acetone (100 ml) was added decyl bromide (10 ml, 50 mmol) and mercaptoethanol (4.4 ml, 63 mmol). The suspension was stirred at room temperature for 2 days, then partitioned between water and 80% hexane/ethyl acetate. The organic phase was washed with 2N sodium hydroxide, dried over magnesium sulfate, and the volatiles removed under vacuum to give 2-(decylthio)ethanol (10.2 g, 47 mmol) as a colorless liquid that was used without further purification.

後処理

  1. custompartitioned between water and 80% hexane/ethyl acetate
  2. washThe organic phase was washed with 2N sodium hydroxide
  3. dry with materialdried over magnesium sulfate
  4. customthe volatiles removed under vacuum

出典と根拠

ORDレコード
ord-76c4d5abcd4a4f9a8133463c6905d816
出典データセット
uspto-grants-2012_01
特許番号
US08101575B2

関連ノート

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