Sulfuric Acid → HCID 86647093、化合物

HRID 421565

反応式

HRID 421565 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[S:28](=[O:32])(=[O:31])([OH:30])[OH:29]>C(O)(C)C>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[S:28]([O-:32])([O-:31])(=[O:30])=[O:29]

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 5002Quetiapine

生成物 1

HCID 86647093HCID 86647093、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
27.5 °C

実験手順

Quetiapine free base (5.0 g) was dissolved in isopropyl alcohol (50 ml) at room temperature. This was followed by addition of 98% sulfuric acid (1.28 g) at 30 to 35° C. The resulting gummy mass was heated to reflux and maintained for 15 minutes. The resulting mass was cooled at 25-30° C. and stirred for 1 hour. The precipitated product was collected by filtration, washed with isopropyl alcohol (25 ml) and dried to give the title compound as off white powder (5.88 g).

後処理

  1. temperatureThe resulting gummy mass was heated
  2. temperatureto reflux
  3. temperaturemaintained for 15 minutes
  4. filtrationThe precipitated product was collected by filtration
  5. washwashed with isopropyl alcohol (25 ml)
  6. customdried

出典と根拠

ORDレコード
ord-4d4e834c097e48cd99a19b42b4acf138
出典データセット
uspto-grants-2012_01
特許番号
US08101597B2

関連ノート

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