Citric Acid → Quetiapine Citrate

HRID 421569

反応式

HRID 421569 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]([OH:40])(=[O:39])[CH2:29][C:30]([CH2:35][C:36]([OH:38])=[O:37])([C:32]([OH:34])=[O:33])[OH:31]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]([O-:40])(=[O:39])[CH2:29][C:30]([CH2:35][C:36]([O-:38])=[O:37])([C:32]([O-:34])=[O:33])[OH:31]

参加物

4

反応物 2

HCID 311Citric AcidHCID 5002Quetiapine

生成物 1

HCID 86647095Quetiapine Citrate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of citric acid (1.1 g) at 30 to 35° C. The resulting mass was heated at reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.95 g).

後処理

  1. temperatureThe resulting mass was heated
  2. temperatureat reflux
  3. temperaturemaintained for 30 minutes
  4. distillationThis was followed by the distillation of acetone
  5. customobtained solid
  6. customwas further dried under vacuum

出典と根拠

ORDレコード
ord-4a3066286e1c48888a8b6017ba2bc218
出典データセット
uspto-grants-2012_01
特許番号
US08101597B2

関連ノート

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