Morpholine → N-(3-benzamido-4-chlorophenyl)-6-(morpholinomethyl)nicotinamide

反応式

[C:1]([NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([CH2:25]Br)=[N:21][CH:20]=2)[CH:13]=[CH:14][C:15]=1[Cl:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[C:1]([NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[N:21][CH:20]=2)[CH:13]=[CH:14][C:15]=1[Cl:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 8083Morpholine

HCID 16730952N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamide

生成物 1

HCID 16730953N-(3-benzamido-4-chlorophenyl)-6-(morpholinomethyl)nicotinamide

実験手順

N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamide (0.11 mmol) was used in general procedure 5 with morpholine (0.12 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-6-(morpholinomethyl)nicotinamide. MS (Q1) 450.0 (M)+

後処理

customThe product was purified by RP-HPLC

出典と根拠

ORDレコード: ord-24bf55076b734f738a6a5164f9260eea
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08101610B2

反応ノート

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