1-Ethylpiperazine → 6-(4-Ethylpiperazin-1-yl)nicotinamide

反応式

Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC=C(Cl)C=3)C=2)=[O:7])=[CH:4][N:3]=1.[CH2:28]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)[CH3:29]>>[CH2:28]([N:30]1[CH2:35][CH2:34][N:33]([C:2]2[CH:27]=[CH:26][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=2)[CH2:32][CH2:31]1)[CH3:29]

参加物

反応物 2

HCID 791961-Ethylpiperazine

HCID 167312706-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide

生成物 1

HCID 187964306-(4-Ethylpiperazin-1-yl)nicotinamide

実験手順

6-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide (0.16 mmol) was used in general procedure 3 with 1-ethylpiperazin (0.83 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(3-chlorobenzamido)phenyl))-6-(4-ethylpiperazin-1-yl)nicotinamide. MS (Q1) 498.1 (M)+

後処理

customThe product was purified by RP-HPLC

出典と根拠

ORDレコード: ord-9cb838b272034a5aa9aed247980aafd7
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08101610B2

反応ノート

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