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Ethyl 6-chloronicotinate → 6-[(R)-4-(4-Benzyl-phthalazin-1-yl)-2-methyl-piperazin-1-yl]-nicotinic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 6-chloronicotinate | HCID 2799611 | — |
| 反応物 | 1-Benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine | HCID 44186248 | — |
| 生成物 | 6-[(R)-4-(4-Benzyl-phthalazin-1-yl)-2-methyl-piperazin-1-yl]-nicotinic acid ethyl ester | HCID 59240661 | 71.1% |
反応手順
Following the above procedure, 6-chloronicotinic acid ethyl ester (100 mg, 0.54 mmol, 1.7 eq) and 1-benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine (100 mg, 0.31 mmol, 1.0 eq) afford the title compound as a white solid (103 mg, 71% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536168B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-526bb1fb44604fb196db5f4a9db53633 |
| 出典メモ | uspto-grants-2013_09 |