Methanol → 4-Bromo-6-(methoxycarbonyl)pyridine-2-carboxylic acid

HRID 421982ノート

反応式

HRID 421982 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[N:5]=[C:4]([C:12]([O:14]C)=[O:13])[CH:3]=1.[OH-].[K+].CO.C(Cl)Cl>C(OCC)C>[Br:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[N:5]=[C:4]([C:12]([OH:14])=[O:13])[CH:3]=1

参加物

6

反応物 4

HCID 887MethanolHCID 6344DichloromethaneHCID 14797Potassium HydroxideHCID 11953411HCID 11953411、化合物

生成物 1

HCID 469414564-Bromo-6-(methoxycarbonyl)pyridine-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 6.09 g of dimethyl 4-bromopyridine-2,6-dicarboxylate, 1.08 g of potassium hydroxide, 200 ml of methanol and 20 ml of methylene chloride was stirred at room temperature for 3 hours, and 200 ml of diethylether was added thereto. The resulting white solid was filtered, and then washed with ether. The obtained white solid was dissolved in water, and then 12 ml of hydrochloric acid (2 M) was added thereto. The resulting mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated in vacuo to give the title compound.

後処理

  1. filtrationThe resulting white solid was filtered
  2. washwashed with ether
  3. dissolutionThe obtained white solid was dissolved in water
  4. addition12 ml of hydrochloric acid (2 M) was added
  5. extractionThe resulting mixture was extracted with chloroform
  6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  7. filtrationfiltered
  8. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-7c1c99340a9344178cb952ddeb941d5c
出典データセット
uspto-grants-2012_01
特許番号
US08101621B2

反応ノート

読み込み中…