関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 5-Fluoro-2-nitrotoluene | HCID 94956 | — |
| 反応物 | 4H,5H-furo(3,2-c)pyridin-4-one | HCID 288746 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(3-methyl-4-nitrophenyl)furo[3,2-c]pyridin-4(5H)-one | HCID 58015566 | 108.6% |
反応手順
4-Fluoro-2-methyl-1-nitrobenzene (2.3 mL, 19 mmol) was added to a suspension of furo[3,2-c]pyridin-4(5H)-one (2.115 g, 15.67 mmol) and Cs2CO3 (5.097 g, 15.67 mmol) in anhydrous DMF (100 mL) and the resulting suspension was heated to 125° C. and stirred for 15 h. H2O was added and the aqueous suspension was filtered. The solid was dried under reduced pressure to afford 4.6 g of crude 5-(3-methyl-4-nitrophenyl)furo[3,2-c]pyridin-4(5H)-one, which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08101632B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-38672bfa8ebe4c00a85c3504a8040464 |
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| 出典メモ | uspto-grants-2012_01 |
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