2-Chloromethyl-imidazo(1,2-A)pyridine → Imidazo(1,2-a)pyridine

HRID 422278ノート

反応式

HRID 422278 の反応式
ClC[C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1>C([O-])(O)=O.[Na+]>[N:4]1[CH:3]=[CH:11][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12

参加物

3

反応物 1

HCID 9576142-Chloromethyl-imidazo(1,2-A)pyridine

生成物 1

HCID 78960Imidazo(1,2-a)pyridine収率 80%

試薬・触媒・溶媒 1

HCID 516892Sodium Bicarbonate溶媒

実験手順

To saturated NaHCO3 (40 mL) was added the chlorhydrate form of 2-(chloromethyl)-imidazo[1,2-a]pyridine and the aqueous layer was extracted with AcOEt. The organic layers were combined and washed with brine, dried over MgSO4 and the solvent was removed under reduced pressure to afford 877 mg of 2-chloromethyl)-imidazo[1,2-a]pyridine (Yield. 80%) as a brownish solid (M.P.: 8485° C.)

後処理

  1. extractionthe aqueous layer was extracted with AcOEt
  2. washwashed with brine
  3. dry with materialdried over MgSO4
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-87acddfc0a9e4ecc9b0e7604d463773c
出典データセット
uspto-grants-2012_01
特許番号
US08101637B2

反応ノート

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