3-Butyn-1-OL → 2-(but-3-ynyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

HRID 422284

反応式

HRID 422284 の反応式
[N:1]1[NH:2][C:3](=[O:10])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[CH2:11](O)[CH2:12][C:13]#[CH:14]>>[CH2:14]([N:2]1[C:3](=[O:10])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]2=[N:1]1)[CH2:13][C:12]#[CH:11]

参加物

3

反応物 2

HCID 135663-Butyn-1-OLHCID 814311,2,4-Triazolo(4,3-a)pyridin-3(2H)-one

生成物 1

HCID 636564482-(but-3-ynyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one収率 26.3%

実験手順

The title compound was prepared in accordance with the general method of Example 109(D), from [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (405 mg, 3.00 mmol) and but-3-yn-1-ol (200 mg, 2.85 mmol). The crude residue was purified by flash chromatography (DCM/MeOH 99:1) to yield 140 mg (0.75 mmol, 26%) of 2-(but-3-ynyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one.

後処理

  1. customThe crude residue was purified by flash chromatography (DCM/MeOH 99:1)

出典と根拠

ORDレコード
ord-d99ada4a253548d4870fe3b539248d86
出典データセット
uspto-grants-2012_01
特許番号
US08101637B2

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