関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine | HCID 667618 | — |
| 反応物 | 4,7-Dichloro-1H-imidazo(4,5-d)pyridazine | HCID 5302825 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 178506202 | HCID 178506202 | 57% |
反応手順
4,7-Dichloro-1H-imidazo[4,5-d]pyridazine (250 mg, 1.32 mmol) is combined with triethylamine (270 μL), dioxane (2 mL), and 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine (290 mg, 1.26 mmol). The reaction mixture is heated to 80° C. for 70 h. Concentrate in vacuo to remove dioxane. The residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2) to afford the title compound (176 mg, 57%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08536168B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-8193877e583f4d049808c1e95cd14127 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
