2-Methyl-6-fluoroquinoxaline → 6-Fluoro-2-(4-trimethylsilanyl-but-3-ynyl)-quinoxaline

HRID 422386ノート

反応式

HRID 422386 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[N:5]2.FC1[C:15]([CH:24]([CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])CC)=NC2C(N=1)=CC=CC=2>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12][CH2:15][C:24]#[C:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[CH:6]=[N:5]2

参加物

3

反応物 2

HCID 133808502-Methyl-6-fluoroquinoxalineHCID 66675154Fluoro-2-(4-trimethylsilanyl-but-3-yl)-quinoxaline

生成物 1

HCID 665983606-Fluoro-2-(4-trimethylsilanyl-but-3-ynyl)-quinoxaline

実験手順

The title compound was prepared in accordance with the general method of Example 118(A), from 6-fluoro-2-methyl-quinoxaline (100 mg, 0.62 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1) to yield 66 mg (0.24 mmol, 39%) of 6 fluoro-2-(4-trimethylsilanyl-but-3-yl)-quinoxaline as an orange oil.

後処理

  1. customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1)

出典と根拠

ORDレコード
ord-9e4cc201c2c14de88a47b86b9336f654
出典データセット
uspto-grants-2012_01
特許番号
US08101637B2

反応ノート

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