2-Bromopyridine → 1(2H)-Isoquinolinone

HRID 422428

反応式

HRID 422428 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([N:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22])[CH2:9][C:10]#[CH:11]>>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:11]#[C:10][CH2:9][CH2:8][N:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22].[C:13]1(=[O:22])[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[CH:21][NH:12]1

参加物

4

反応物 2

HCID 79732-BromopyridineHCID 818837422-but-3-ynyl-2H-isoquinolin-1-one

生成物 2

HCID 102841(2H)-IsoquinolinoneHCID 665980982-(4-(Pyridin-2-yl)but-3-ynyl)isoquinolin-1(2H)-one

実験手順

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (100 mg, 0.63 mmol) and 2-but-3-ynyl-2H-isoquinolin-1-one (120 mg, 0.63 mmol). Reaction time: 3 hours. The crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1) to yield 17 mg (62 μmol, 10%) of 2-(4-pyridin-2-yl)but-3-ynyl)isoquinolin-1(2H)-one as a white solid (M.P.=85-90° C.).

後処理

  1. customReaction time
  2. custom3 hours
  3. customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1)

出典と根拠

ORDレコード
ord-b9846b67a4a54a75815a0b62dc7fd417
出典データセット
uspto-grants-2012_01
特許番号
US08101637B2

関連ノート

読み込み中…