2-Amino-3-chloropyridine → 8-Chloro-2-(4-(trimethylsilyl)but-3-ynyl)-imidazo[1,2-a]pyridine
反応式
Br[CH2:2][C:3](=O)[CH2:4][CH2:5][C:6]#[C:7][Si:8]([CH3:11])([CH3:10])[CH3:9].[Cl:13][C:14]1[C:15]([NH2:20])=[N:16][CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[C:15]2[N:16]([CH:2]=[C:3]([CH2:4][CH2:5][C:6]#[C:7][Si:8]([CH3:11])([CH3:10])[CH3:9])[N:20]=2)[CH:17]=[CH:18][CH:19]=1参加物
3
実験手順
The title compound was prepared in accordance with the general method of Example 223(D), from 1-bromo-6-(trimethylsilyl)hex-5-yn-2-one (4.96 g, 20.1 mmol, Example 223(C)) and 3-chloropyridin-2-amine (1.29 g, 10.0 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1) to yield 2.00 g (7.22 mmol, 72%) of 8-chloro-2-(4-(trimethylsilyl)but-3-ynyl)-imidazo[1,2-a]pyridine as a brown solid.
後処理
- customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1)
出典と根拠
- ORDレコード
- ord-f60ff32a0f7a4a15a89f99ca0c8f2e31
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101637B2
反応ノート
読み込み中…