8-Chloro-2-(4-(trimethylsilyl)but-3-ynyl)-imidazo[1,2-a]pyridine → 2-(But-3-ynyl)-8-chloro-imidazo[1,2-a]pyridine
反応式
[Cl:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH2:12][C:13]#[C:14][Si](C)(C)C)[N:10]=2)[CH:5]=[CH:6][CH:7]=1>CCOCC>[CH2:11]([C:9]1[N:10]=[C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][N:4]2[CH:8]=1)[CH2:12][C:13]#[CH:14]参加物
3
実験手順
The title compound was prepared in accordance with the general method of Example 108(B), from 8-chloro-2-(4-(trimethylsilyl)but-3-ynyl)-imidazo[1,2-a]pyridine (2.00 g, 7.22 mmol). The crude residue was taken in Et2O, filtered and concentrated to yield 1.09 mg (5.31 mmol, 74%) of 2-(but-3-ynyl)-8-chloro-imidazo[1,2-a]pyridine as a yellow solid.
後処理
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-4084e8f65f1d4b879c839afd7e231d91
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101637B2
反応ノート
読み込み中…