関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Chlorophenyl cyclopropyl ketone | HCID 81148 | — |
| 反応物 | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime | HCID 73696106 | 87.4% |
反応手順
Methoxylamine hydrochloride (2.004 g) was added to (4-chlorophenyl)(cyclopropyl)methanone (2.71 g) in pyridine (60 mL) at 25° C. The resulting solution was stirred at 25° C. for 24 hours. The pyridine was removed in vacuo, and the residual solid extracted with ether. Filtration and evaporation of the solvent gave the crude (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime (2.75 g, 87%) as a yellow oil. This material was used directly in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08101623B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-820c7f43ceda4a6a8685cd0aafeb45e2 |
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| 出典メモ | uspto-grants-2012_01 |
|---|
