Hydrochloric Acid → methyl (3R)-3-amino-3-(4-chlorophenyl)propanoate

HRID 423059ノート

反応式

HRID 423059 の反応式
Cl.C(OC([NH:9][C@@H:10]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[CH2:11][C:12]([O:14][CH3:15])=[O:13])=O)(C)(C)C>C(Cl)Cl>[NH2:9][C@@H:10]([C:16]1[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=1)[CH2:11][C:12]([O:14][CH3:15])=[O:13]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57750353HCID 57750353、化合物2 回

生成物 1

HCID 2400965methyl (3R)-3-amino-3-(4-chlorophenyl)propanoate収率 115.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
20 °C

実験手順

Hydrochloric acid (4.0M in dioxane) (7.89 mL, 31.55 mmol) was added in one portion to (R)-methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate (Intermediate 39) (990 mg, 3.16 mmol) in DCM (20 mL) at 20° C. The resulting solution was stirred at 20° C. for 3 hours. The reaction mixture was evaporated to afford (R)-methyl 3-amino-3-(4-chlorophenyl)propanoate (hydrochloride) (777 mg, 98%) as a yellow solid.

後処理

  1. customThe reaction mixture was evaporated

出典と根拠

ORDレコード
ord-36d53d0f380948e3a841cb5ab579dc02
出典データセット
uspto-grants-2012_01
特許番号
US08101623B2

反応ノート

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