Piperidine → 4-(2-Butynyloxy)-5-fluoro-6-piperidinopyrimidine
反応式
[CH2:1]([O:5][C:6]1[C:11]([F:12])=[C:10](F)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>C1(C)C=CC=CC=1>[CH2:1]([O:5][C:6]1[C:11]([F:12])=[C:10]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4]参加物
4
実験手順
0.2 g of 4-(2-butynyloxy)-5,6-difluoropyrimidine and 0.12 g of piperidine were added to 0.3 ml of toluene, then the mixture was stirred at room temperature for 3 hours. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.25 g of 4-(2-butynyloxy)-5-fluoro-6-piperidinopyrimidine (referred as the present compound (2) hereinafter).
出典と根拠
- ORDレコード
- ord-0c6b79f46c9a4a0f85a73a681673eb30
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101753B2
反応ノート
読み込み中…