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3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| 反応物 | 4-(2-Butynyloxy)-6-fluoropyrimidine | HCID 59661969 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine | HCID 57672951 | — |
反応手順
0.2 g of 4-(2-butynyloxy)-6-fluoropyrimidine and 0.15 g of 3-trifluoromethylpiperidine are added to 1 ml of toluene, then the mixture is stirred at room temperature for 30 minutes. Then the reaction mixture is subjected to silica gel column chromatography to obtain 4-(2-butynyloxy)-6-(3-trifluoromethylpyperidino)pyrimidine (referred as the present compound (10) hereinafter).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08101753B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-396961e1920d455cb9aea8f8df2fdd63 |
| 出典メモ | uspto-grants-2012_01 |