Methanol → Dimethyl 4-hydroxyisophthalate

HRID 423264ノート

反応式

HRID 423264 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.[C:19](=O)(O)[O-].[Na+].[CH3:24][OH:25]>O>[CH3:24][O:25][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[C:3]([C:11]([O:13][CH3:19])=[O:12])[CH:4]=1

参加物

6

反応物 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 124904-Hydroxyisophthalic acidHCID 516892Sodium Bicarbonate

生成物 1

HCID 80087Dimethyl 4-hydroxyisophthalate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 4-hydroxyisophthalic acid (16.0 g) in methanol (150 mL) was added conc. sulfuric acid (5 mL), and the mixture was heated for 22 hours under reflux. Then, the reaction solution was allowed to stand for cooling down to room temperature, diluted with water (150 mL), and added with sodium bicarbonate (15 g). The resulting precipitate was filtered, washed successively with water/methanol (1:1, v/v) (150 mL) and water, and dried to give the title compound (17.45 g).

後処理

  1. temperaturethe mixture was heated for 22 hours
  2. temperatureunder reflux
  3. filtrationThe resulting precipitate was filtered
  4. washwashed successively with water/methanol (1:1
  5. dry with materialv/v) (150 mL) and water, and dried

出典と根拠

ORDレコード
ord-30654b4550c94ee293b82d838b3f59c9
出典データセット
uspto-grants-2012_01
特許番号
US08101774B2

反応ノート

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