Ethanol → Ethyl 3-bromo-2,2-dimethylpropanoate

HRID 423301ノート

反応式

HRID 423301 の反応式
[Br:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH3:14][CH2:15]O>>[Br:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([O:6][CH2:14][CH3:15])=[O:5]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 2719323-Bromo-2,2-dimethylpropanoic acid

生成物 1

HCID 12373576Ethyl 3-bromo-2,2-dimethylpropanoate

実験手順

3-Bromo-2,2-dimethylpropanoic acid (200 mg) was dissolved in EtOH (5 ml) and treated with concentrated H2SO4 (0.4 ml). This mixture was heated at reflux overnight then evaporated. The residue was extracted from H2O with EtOAc (×2) and the combined organic solutions dried and evaporated to give the title compound (316 mg) as a clear oil. δH (CDCl3, 400 MHz) 1.20 (3H, t), 1.32 (6H, s), 3.51 (2H, s), 4.18 (2H, q).

後処理

  1. temperatureThis mixture was heated
  2. temperatureat reflux overnight
  3. customthen evaporated
  4. extractionThe residue was extracted from H2O with EtOAc (×2)
  5. customthe combined organic solutions dried
  6. customevaporated

出典と根拠

ORDレコード
ord-a01ad34764be4e8ca509ba0e5feb857c
出典データセット
uspto-grants-2012_01
特許番号
US08101775B2

反応ノート

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