関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate | HCID 59318406 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178471833 | HCID 178471833 | 103.9% |
反応手順
Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate (D54) (3.44 g), NH2OH.HCl (1.97 g) and Na2CO3 (5.96 g) were dissolved in EtOH (75 ml). This mixture was heated at 50° C. overnight. A further portion of NH2OH.HCl (985 mg) was added and the mixture stirred at 70° C. overnight. The reaction mixture was then filtered and evaporated to give the title compound (4.06 g). MS (ES): C14H17N3O3 requires 275; found 276 (MH+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08101775B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-dd893dce617e4ced8e0a263297264b48 |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
