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(4-(Methylsulfinyl)phenyl)boronic acid → (+/-)-1-Methylethyl 4-({[4'-(methylsulfinyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4-(Methylsulfinyl)phenyl)boronic acid | HCID 2773531 | — |
| 反応物 | 4-(4-Bromophenoxymethyl)piperidine-1-carboxylic acid isopropyl ester | HCID 57930300 | — |
| 生成物 | (+/-)-1-Methylethyl 4-({[4'-(methylsulfinyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate | HCID 59177838 | 16% |
反応手順
The title compound (6.6 mg, 16%) was prepared from (±)-[4-(methylsulfinyl)phenyl]boronic acid (18.4 mg, 0.1 mmol) and 1-methylethyl 4-{[(4-bromophenyl)oxy]methyl}-1-piperidinecarboxylate (Example 9, Step 2, 36 mg, 0.10 mmol) in a manner similar to Example 9, Step 3. LRMS (ESI), m/z 416 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08101634B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-c36b82f422634eaeb7a90e23b7b4def4 |
| 出典メモ | uspto-grants-2012_01 |