関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | N-(2,5-difluorophenyl)benzenesulfonamide | HCID 8500589 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,5-difluoro-4-nitro-N-benzenesulphonylaniline | HCID 20151986 | — |
反応手順
To 310 ml of acetic acid diluted with 160 ml of water are added: 1.5 g of sodium nitrite, 0.16 mole (42 g) of 2,5-difluoro-N-benzenesulphonylaniline prepared in the previous stage and 0.94 mole (39 ml) of nitric acid (d=1.52). The reaction mixture is heated to 96° C. for 1 hour. After cooling it is poured onto 1 kg of ice and water. The expected product precipitates. After being filtered off and washed to neutrality it is recrystallized from 250 ml of acetic acid; it melts at 176° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04725283 |
|---|
| 出典データセット | uspto-grants-1988_02 |
|---|
| ORD ID | ord-6690a163904649839ee51f83c59f74e3 |
|---|
| 出典メモ | uspto-grants-1988_02 |
|---|
