Hydrochloric Acid → 1-(Trifluoromethyl)cyclopropanamine hydrochloride

反応式

[F:1][C:2]([F:15])([F:14])[C:3]1([NH:6]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1.[ClH:16]>>[ClH:16].[F:1][C:2]([F:15])([F:14])[C:3]1([NH2:6])[CH2:5][CH2:4]1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 11658639Tert-butyl [1-(trifluoromethyl)cyclopropyl]carbamate

生成物 1

HCID 116511961-(Trifluoromethyl)cyclopropanamine hydrochloride収率 91%

実験手順

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

後処理

temperatureat reflux for 3.5 h
concentrationThe solution was concentrated in vacuo
customthe residue was triturated with acetone
customThe filtrate was collected
concentrationconcentrated
customthe residue triturated with diethyl ether

出典と根拠

ORDレコード: ord-156c063e1b044551b05abc469f8230ec
出典データセット: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08536187B2

反応ノート

読み込み中…

参加物