関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 6-Chloro-3-phenyl-1,5-naphthyridin-2(1H)-one | HCID 66524919 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 6-Hydrazinyl-3-phenyl-1,5-naphthyridin-2(1H)-one | HCID 67069008 | — |
反応手順
A mixture of 6-chloro-3-phenyl-1,5-naphthyridin-2(1H)-one (7-1) (1.4 g, 5.61 mmol) and hydrazine hydrate (2 g, 40 mmol) in pyridine (18 mL) was heated under microwave irradiation at 160° C. for 1.5 hours. To the mixture was added Et2O and water, and the resulting solid was collected by filtration to give 6-hydrazino-3-phenyl-1,5-naphthyridin-2(1H)one (7-2) as orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08536193B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-1743d55a84284d259933a725ef93c5da |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
