Dimethylformamide dimethyl acetal → HCID 76548813、化合物

HRID 423765ノート

反応式

HRID 423765 の反応式
[CH2:1]([O:3][C:4](=[O:18])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([N+:14]([O-:16])=[O:15])[C:6]=1[CH3:17])[CH3:2].CO[CH:21]([N:24]([CH3:26])[CH3:25])OC>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:18])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([N+:14]([O-:16])=[O:15])[C:6]=1[CH:17]=[CH:21][N:24]([CH3:26])[CH3:25])[CH3:2]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 43386560Ethyl 2-methyl-3,5-dinitrobenzoate

生成物 1

HCID 76548813HCID 76548813、化合物収率 48%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2-methyl-3,5-dinitro-benzoic acid ethyl ester (35 g, 0.14 mol) and dimethoxymethyl-dimethyl-amine (32 g, 0.27 mol) in DMF (200 mL) was heated at 100° C. for 5 h. The mixture was poured into ice-water. The precipitate was collected via filtration and washed with water to give 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester (11.3 g, 48%).

後処理

  1. filtrationThe precipitate was collected via filtration
  2. washwashed with water

出典と根拠

ORDレコード
ord-05ea768d575d4bc6bca1e997ae052d8a
出典データセット
uspto-grants-2012_01
特許番号
US08101767B2

反応ノート

読み込み中…