Dimethyl Sulfoxide → 2,2-Diphenyl-4-oxo-butyric acid methyl ester

HRID 424167

反応式

HRID 424167 の反応式
[CH3:1][O:2][C:3](=[O:20])[C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:5][CH2:6]Br.C[N+]([O-:25])(C)C.CS(C)=O>>[CH3:1][O:2][C:3](=[O:20])[C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:5][CH:6]=[O:25]

参加物

4

反応物 3

HCID 679Dimethyl SulfoxideHCID 1145Trimethylamine oxideHCID 22624494Methyl 4-bromo-2,2-diphenylbutyrate

生成物 1

HCID 866311002,2-Diphenyl-4-oxo-butyric acid methyl ester

実験手順

A mixture of 4-bromo-2,2-diphenyl-butyric acid methyl ester (0.10 g, 0.300 mmol) and trimethylamine N-oxide (0.09 g, 1.2 mmol) in dimethyl sulfoxide (0.5 mL, 7 mmol) was stirred overnight at room temperature. The reaction was quenched with cold brine. The crude product was extracted three times with dichloromethane, dried over a bed of Na2SO4, filtered, and concentrated to dryness to provide crude title compound which was used without further purification.

後処理

  1. customThe reaction was quenched with cold brine
  2. extractionThe crude product was extracted three times with dichloromethane
  3. dry with materialdried over a bed of Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-1c4bc66244d645269d180f2481cccfeb
出典データセット
uspto-grants-2012_01
特許番号
US08101791B2

関連ノート

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